Ethanol → HCID 54527564, Verbindung

HRID 1637933Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1637933
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14])([O-])=O.NC1SC=C(C2C=CC(N)=CC=2)N=1.CCO>CN(C=O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14]

Komponenten

6

Edukt 3

HCID 702EthanolHCID 3778255-(3-nitrobenzylidene)imidazolidine-2,4-dioneHCID 6055642-Amino-4-(4-aminophenyl)thiazole

Produkt 1

HCID 54527564HCID 54527564, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2.3 g (10 mmol) of crude 3-nitro-benzylidene-hydantoin, melting point 280-284° C., (prepared as described in Example 6 in (a)) are hydrogenated in 60 ml of DMF and 40 ml EtOH on 2 g of Raney nickel for 36 hours at 20° C. and 3.5 bar. It is filtered over kieselguhr and the filtrate is evaporated down in vacuo. The evaporation residue is crystallised with ether.

Aufarbeitung

  1. filtrationIt is filtered over kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. customThe evaporation residue is crystallised with ether

Quellen und Nachweise

ORD-Eintrag
ord-868b03d787424b74b9f08e5b99c7e1e2
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06043254

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