Ethyl chloroformate → HCID 14648418, Verbindung

HRID 1638287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1638287
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[C:22](Cl)(=[O:26])[O:23][CH2:24][CH3:25]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:22]([O:23][CH2:24][CH3:25])=[O:26])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

Komponenten

4

Edukt 2

HCID 10928Ethyl chloroformateHCID 3082453Hpr 611

Produkt 1

HCID 14648418HCID 14648418, VerbindungAusbeute 81,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After ethyl chlorocarbonate (1.5 g) was dropwise added to the solution, the resultant was stirred for 8 hours at 80° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from a mixture of chloroform and ethanol to yield the title compound as colorless crystals (3.2 g). mp 196°-197° C.

Aufarbeitung

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from a mixture of chloroform and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ae96f7b61a1f4a558cf91b40802ca34e
Quelldatensatz
uspto-grants-1989_11
Patentnummer
US04879301

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