Methyl Isocyanate → HCID 14601660, Verbindung

HRID 1638288Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1638288
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[CH3:22][N:23]=[C:24]=[O:25]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:24](=[O:25])[NH:23][CH3:22])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

Komponenten

4

Edukt 2

HCID 12228Methyl IsocyanateHCID 3082453Hpr 611

Produkt 1

HCID 14601660HCID 14601660, VerbindungAusbeute 71,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After methyl isocyanate (0.9 g) was dropwise added to the solution, the resultant was stirred for 15 hours at 30° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from methanol to yield the title compound as colorless crystals (2.7 g). mp 202°-203° C.

Aufarbeitung

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-971f1681d3e74e3b9c571b190f6cc604
Quelldatensatz
uspto-grants-1989_11
Patentnummer
US04879301

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