6,7-Dimethoxy-2-naphthoic acid → HCID 14676175, Verbindung

HRID 1638810Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1638810
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([OH:17])=O)[CH:7]=[CH:6]2.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:31]=[C:32]([O:36][CH3:37])[C:33]=1[O:34][CH3:35])[C:23]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)=[O:24]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]=[C:8]([C:15]([N:28]1[CH2:29][CH2:30][N:25]([C:23](=[O:24])[C:22]3[CH:31]=[C:32]([O:36][CH3:37])[C:33]([O:34][CH3:35])=[C:20]([O:19][CH3:18])[CH:21]=3)[CH2:26][CH2:27]1)=[O:17])[CH:7]=[CH:6]2

Komponenten

3

Edukt 2

HCID 2830286,7-Dimethoxy-2-naphthoic acidHCID 2874204Piperazine, 1-(3,4,5-trimethoxybenzoyl)-

Produkt 1

HCID 14676175HCID 14676175, Verbindung

Versuchsvorschrift

In a manner as that described in Example 62, 6,7-dimethoxy-2-naphthoic acid and 1-(3,4,5-trimethoxybenzoyl)piperazine are subjected to amidation to give 1-(6,7-dimethoxy-2-naphthoyl)-4-(3,4,5-trimethoxybenzoyl)piperazine. This product is recrystallized from ethyl acetate to give colorless needles, m.p. 224°-226° C.

Quellen und Nachweise

ORD-Eintrag
ord-51df90c591be4aafad0cba5ecd5912ba
Quelldatensatz
uspto-grants-1989_11
Patentnummer
US04880809

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