Reaktionsgleichung
[CH3:1][O:2][C:3]1[C:4]([O:36][CH3:37])=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][C:9]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:34])[C:22]4[CH:27]=[C:26]([O:28][CH3:29])[C:25]([O:30][CH3:31])=[C:24]([O:32][CH3:33])[CH:23]=4)[CH2:17][CH2:16]3)=[O:14])=[CH:8][C:7]=2[CH:35]=1.[H][H]>C(O)C.[C].[Pd]>[CH3:37][O:36][C:4]1[C:3]([O:2][CH3:1])=[CH:35][C:7]2[CH2:8][CH:9]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:34])[C:22]4[CH:23]=[C:24]([O:32][CH3:33])[C:25]([O:30][CH3:31])=[C:26]([O:28][CH3:29])[CH:27]=4)[CH2:17][CH2:16]3)=[O:14])[CH2:10][CH2:11][CH2:12][C:6]=2[CH:5]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of 1-(2,3-dimethoxy-6,7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine (1.0 g) obtained in Example 62 in ethanol (50 ml) is added 10% palladium-carbon (50 mg), followed by catalytic reduction in a stream of hydrogen. The reaction mixture is filtered off, and the filtrate is concentrated under reduced pressure. To the residue is added ether, and the mixture is stirred to obtain 1-(2,3-dimethoxy-5,6,7,8-tetrahydrobenzocyclohepten-6-ylcarbonyl)-4-(3,4,5-trimethoxy-benzoyl)piperazine as a colorless powder.
Aufarbeitung
- filtrationThe reaction mixture is filtered off
- concentrationthe filtrate is concentrated under reduced pressure
- additionTo the residue is added ether
Quellen und Nachweise
- ORD-Eintrag
- ord-345238a75d0140b4b94427158b3d982b
- Quelldatensatz
- uspto-grants-1989_11
- Patentnummer
- US04880809
Verknüpfte Notizen
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