1-Pentanol → 5-Pentyloxy-pyrrolidin-2-one
Reaktionsgleichung
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH3:12]>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1)[CH2:9][CH2:10][CH2:11][CH3:12]Komponenten
3
Versuchsvorschrift
2.5 g of 5-hydroxy-pyrrolidin-2-one and 1.25 g of Amberlite IR 120H are heated to 65° C. for 3 hours in 55 cm3 of 1-pentanol. The resin is filtered off, and the remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar. The residue is chromatographed on silica (eluent: ethyl acetate), and 2.68 g of the expected product is obtained. m.p. 42°-43° C.
Aufarbeitung
- filtrationThe resin is filtered off
- distillationthe remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar
- customThe residue is chromatographed on silica (eluent: ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-2da8a7d65e384104a555b0c5607d181e
- Quelldatensatz
- uspto-grants-1989_11
- Patentnummer
- US04882350
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