Imidazolone → 2-acetamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide

HRID 1639462

Reaktionsgleichung

Reaktionsgleichung von HRID 1639462
[CH:1]([C:4]1([CH3:21])[C:8](=[O:9])[N:7]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[C:6]([CH3:20])=[N:5]1)([CH3:3])[CH3:2].N1C(=[O:27])CN=C1>C(Cl)Cl>[C:6]([NH:5][C:4]([CH3:21])([CH:1]([CH3:3])[CH3:2])[C:8]([NH:7][S:10]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)(=[O:12])=[O:11])=[O:9])(=[O:27])[CH3:20]

Komponenten

4

Edukt 2

HCID 504ImidazoloneHCID 146246604-Isopropyl-2,4-dimethyl-1-(p-tolylsulfonyl)-2-imidazolin-5-one

Produkt 1

HCID 146246882-acetamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The reaction mixture is checked for completeness of formation of 4-isopropyl-2,4-dimethyl-1-(p-tolylsulfonyl)-2-imidazolin-5-one by infrared spectroscopy. The product imidazolin-5-one is then hydrolyzed by diluting the solution with 100 mL of methylene cloride and washing twice with water and once with HCl 10%. The organic layer is concentrated in vacuo and the resulting yellowish oily residue is shaken with ether and allowed to stand. Upon standing the title product precipitates as a white solid, which after filtration, washing and drying has a mp of 202°-203° C.

Aufarbeitung

  1. washwashing twice with water and once with HCl 10%
  2. concentrationThe organic layer is concentrated in vacuo
  3. customprecipitates as a white solid, which
  4. filtrationafter filtration
  5. washwashing
  6. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-71e4e1b8424849c2b35acbd7a5f7a36c
Quelldatensatz
uspto-grants-1989_11
Patentnummer
US04883914

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