3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol → (2Z)-3-(2-methyl-2H-indazol-4-yl)prop-2-en-1-ol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Under hydrogen gas atmosphere, a mixture of 3-(2-methyl-2H-indazol-4-yl)prop-2-yn-1-ol (50.0 mg, 0.269 mmol) and 5% palladium-calcium carbonate (lead poisoned, Lindlar catalyst, 5 mg) in methanol (3 mL) was stirred at −10° C. for 90 min, and filtered. The solvent was evaporated under reduced pressure. The residue was washed with diisopropyl ether to give the title compound (41.6 mg, yield 82%).

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