Potassium Carbonate → 2-(3-Methylpyridin-4-yl)-7-[5-(trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	1,4-Dioxane	HCID 31275	—
Edukt	4-Bromo-3-methylpyridine	HCID 428351	—
Edukt	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine	HCID 13822957	—
Edukt	7-[5-(Trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one	HCID 66722301	—
Katalysator	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Produkt	2-(3-Methylpyridin-4-yl)-7-[5-(trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one	HCID 57970788	—

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

To a solution of 7-[5-(trifluoromethyl)pyridin-2-yl]-2,7-diazaspiro[4.5]decan-1-one (24.4 mg, 0.0000814 mol) in 1,4-dioxane (0.5 mL, 0.006 mol) were added (1S,2S)—N,N′-dimethylcyclohexane-1,2-diamine (2.3 mg, 0.000016 mol), copper(I) iodide (1.6 mg, 0.0000081 mol), 4-bromo-3-methylpyridine (28 mg, 0.00016 mol) and potassium carbonate (23.6 mg, 0.000171 mol); and the mixture was stirred at 100° C. overnight. The product was purified by prep-HPLC. LC-MS: 391.2 (M+H)+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08110581B2
Quelldatensatz	uspto-grants-2012_02
ORD ID	ord-5ddad58e9c9f44f28a560617bc395aad
Quellennotiz	uspto-grants-2012_02