Hydrochloric Acid → 6-(3-Methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylic acid

HRID 1640231Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1640231
[CH3:1][N:2]1[C:6]2([CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([NH:15][C:16]4[N:21]=[CH:20][N:19]=[C:18]([C:22]([O:24]CC)=[O:23])[CH:17]=4)[CH:12]=3)[CH2:7]2)[C:5](=[O:27])[NH:4][C:3]1=[O:28].[OH-].[Na+].Cl>C(O)C>[CH3:1][N:2]1[C:6]2([CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[C:11]([NH:15][C:16]4[N:21]=[CH:20][N:19]=[C:18]([C:22]([OH:24])=[O:23])[CH:17]=4)[CH:12]=3)[CH2:7]2)[C:5](=[O:27])[NH:4][C:3]1=[O:28]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58117486Ethyl 6-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylate

Produkt 1

HCID 581175346-(3-Methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidin-4,2'-inden]-5'-ylamino)pyrimidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

140 mg (0.37 mmol) ethyl 6-(3-methyl-2,5-dioxo-1′,3′-dihydrospiro[imidazolidin-4,2′-inden]-5′-ylamino)pyrimidine-4-carboxylate, 5 mL ethanol and 1 mL (1.0 mmol) of a 1M NaOH solution were stirred for 2 h at RT. The reaction mixture was combined with 1 mL of a 1M hydrochloric acid solution and the ethanol was eliminated i.vac. The aqueous residue was cooled and the precipitated product was suction filtered, washed with water and dried.

Aufarbeitung

  1. temperatureThe aqueous residue was cooled
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-385dc5426bc14d8f8c5526e6f0846dc0
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08110575B2

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