Aniline → Aniline, N-(2,2,2-trifluoroethyl)-

HRID 1640234

Reaktionsgleichung

Reaktionsgleichung von HRID 1640234
FC(F)(F)S(O[CH2:7][C:8]([F:11])([F:10])[F:9])(=O)=O.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[F:9][C:8]([F:11])([F:10])[CH2:7][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

4

Edukt 2

HCID 6115AnilineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

Produkt 1

HCID 9596Aniline, N-(2,2,2-trifluoroethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

2.5 g (10.7 mmol) 2,2,2-trifluoroethyl trifluoromethanesulphonate were added to 2.0 g (21.5 mmol) aniline in 50 mL xylene and the mixture was refluxed for 2 days. After cooling, the mixture was filtered, washed with DIPE and the filtrate was evaporated down i.vac. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 days
  2. temperatureAfter cooling
  3. filtrationthe mixture was filtered
  4. washwashed with DIPE
  5. customthe filtrate was evaporated down i.vac
  6. customThe residue was purified by flash chromatography
  7. customevaporated down i.vac

Quellen und Nachweise

ORD-Eintrag
ord-1e0a5ea719cf40c5a311b798f7ce4fb7
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08110575B2

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