Ethylenediamine → HCID 68601740, Verbindung

HRID 1640546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1640546
Cl[C:2]1[CH:3]=[CH:4][N:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[CH:8]=[CH:7]2.[CH2:14]([NH2:17])[CH2:15][NH2:16]>C(Cl)Cl>[CH3:13][O:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][CH2:15][CH2:14][NH2:17]

Komponenten

4

Edukt 2

HCID 3301EthylenediamineHCID 222443958-Chloro-2-methoxy-1,5-naphthyridine

Produkt 1

HCID 68601740HCID 68601740, VerbindungAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 8-chloro-2-methoxy-[1,5]naphthyridine (commercial; 1.7 g, 8.80 mmol) and ethane-1,2-diamine (1.2 mL, 2 eq.) was heated slowly to 80° C. over 1 h and subsequently up to 100° C. for 2 h. After cooling to rt, the yellow solution was taken up in DCM and successively washed with sat. aq. NaHCO3. The org. layer was concentrated under reduced pressure to afford the title intermediate as a pale yellow oil (981 mg, 51% yield).

Aufarbeitung

  1. temperatureAfter cooling to rt
  2. washsuccessively washed with sat. aq. NaHCO3
  3. concentrationlayer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-806e442c4a434d4698c807bbab7c71bb
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08114867B2

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