Sulfuric Acid → 1H-indazol-4-ol

HRID 16411

Reaktionsgleichung

Reaktionsgleichung von HRID 16411
[NH:1]1[C:9]2[C:4](=[C:5](N)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.S(=O)(=O)(O)[OH:12].[OH-].[Na+]>>[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([OH:12])[C:4]=2[CH:3]=[N:2]1

Komponenten

4

Edukt 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 413085NoName_3327

Produkt 1

HCID 1357424501H-indazol-4-ol

Versuchsvorschrift

500 mg (375 mmol) of 1H-indazol-4-ylamine (prepared according to J. Chem. Soc. 1955, 2412, 2419) are stirred in 10% strength sulfuric acid at 180° C. in an autoclave at intrinsic pressure overnight. The reaction solution is cooled to room temperature and neutralized with 1N sodium hydroxide solution, and the salts are filtered off. The filtrate is concentrated to dryness.

Aufarbeitung

  1. filtrationthe salts are filtered off
  2. concentrationThe filtrate is concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-3424705caf554a55a61da2572693309a
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737153B2

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