Reaktionsgleichung
Cl.[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9]N.[C:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])(=O)[CH3:12].S(=O)(=O)(O)O.C(=O)([O-])O.[Na+].[CH2:31](O)[CH3:32]>>[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:4]=1[NH:9][C:11]([CH3:12])=[C:14]2[CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:31][CH3:32])=[O:19]Komponenten
6
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
To a solution of (2-bromophenyl)hydrazine hydrochloride (14 g) in ethanol (60 mL), 5-acetylvaleric acid (9.0 g) was added. The reaction mixture was stirred at 50° C. for 40 minutes, and concentrated sulfuric acid (6.0 mL) was added thereto, followed by heating under reflux for 16 hours. The reaction mixture was added to a saturated aqueous sodium hydrogen carbonate solution which was then extracted with ethyl acetate and dried over anhydrous sodium sulfate, followed by concentratration under reduced pressure. The resulting residue was purified by column chromatography (hexane:ethyl acetate=8:1) to obtain the title compound (15 g) having the following physical properties.
Aufarbeitung
- temperatureby heating
- temperatureunder reflux for 16 hours
- extractionwas then extracted with ethyl acetate
- dry with materialdried over anhydrous sodium sulfate
- customThe resulting residue was purified by column chromatography (hexane:ethyl acetate=8:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-dec84ba2ef56459b821ff2aa39e94f50
- Quelldatensatz
- uspto-grants-2012_02
- Patentnummer
- US08115014B2
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