Chloride → 1-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one

HRID 1641666

Reaktionsgleichung

Reaktionsgleichung von HRID 1641666
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Cl-].[NH4+].[CH2:18]1[CH2:22]O[CH2:20][CH2:19]1>>[CH2:1]([N:8]1[C:12]([CH2:20][C:19]2[CH:20]=[CH:19][C:18]([C:22]3[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=3)=[CH:22][CH:18]=2)([OH:13])[CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 4

HCID 312ChlorideHCID 8028Tetrahydrofuran2×HCID 25517Ammonium ChlorideHCID 952411-(Phenylmethyl)-2,5-pyrrolidinedione

Produkt 1

HCID 593184651-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

9.5 g N-Benzylsuccinimide is added to 120 ml THF and the mixture is then cooled to −78° C. A solution of 4-methylbiphenylmagnesium chloride in THF (1.3 eq) is then added. The subsequent mixture is then stirred for 2 h at −78° C. The mixture is then warmed to 10° C. and 100 ml saturated ammonium chloride solution is added. The phases are separated and the aqueous phase is extracted with toluene. The combined organic phases are washed with water then brine and then concentrated in vacuo. The crude material is crystallized from toluene to give 1-Benzyl-5-biphenyl-4-ylmethyl-5-hydroxy-pyrrolidin-2-one. 1H NMR (DMSO): 1.72 (1H), 1.91 (1H), 2.27 (2H), 2.72 (1H), 2.97 (2H), 4.40 (1H), 4.55 (1H), 7.21-7.66 (14H).

Aufarbeitung

  1. temperatureThe mixture is then warmed to 10° C.
  2. customThe phases are separated
  3. extractionthe aqueous phase is extracted with toluene
  4. washThe combined organic phases are washed with water
  5. concentrationbrine and then concentrated in vacuo
  6. customThe crude material is crystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-f33d0f5c9b3142c193ad71d04b1eeda8
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08115016B2

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