tert-Butyl carbamate → (S)-tert-Butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate

HRID 1641782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1641782
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][N:15]=2)C1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:21](OC(=O)N)(C)(C)C>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@H:12]1[CH2:11][CH2:10][N:13]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][N:15]=2)[CH2:21]1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 77922tert-Butyl carbamate2×HCID 57652073HCID 57652073, Verbindung

Produkt 1

HCID 53255818(S)-tert-Butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate

Versuchsvorschrift

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (S)-1-(5-amino-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester was prepared by the hydrogenation of (S)-1-(5-nitro-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester. This material was directly used in the next step without further purification.

Aufarbeitung

  1. customThis material was directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-756b7e1e83cb4c789d979141a480d850
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08115011B2

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