tert-Butyl carbamate → tert-Butyl [(3R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-yl]carbamate

HRID 1641783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1641783
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][N:15]=2)C1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:21](OC(=O)N)(C)(C)C>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@@H:12]1[CH2:11][CH2:10][N:13]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][N:15]=2)[CH2:21]1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 77922tert-Butyl carbamate2×HCID 57652073HCID 57652073, Verbindung

Produkt 1

HCID 53255753tert-Butyl [(3R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-yl]carbamate

Versuchsvorschrift

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (R)-1-(5-amino-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester was prepared by the hydrogenation of (R)-1-(5-nitro-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester. This material was directly used in the next step without further purification.

Aufarbeitung

  1. customThis material was directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7613b39f42d64b8eba825758081ec97e
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08115011B2

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