HCID 57652073, Verbindung → HCID 57652026, Verbindung

HRID 1641784Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1641784
[C:1](OC(N1CC[C@H](NC2C=CC(N)=CN=2)C1)=O)(C)(C)C.[CH3:21][O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24].COC([C@@H]1CC[C@H](NC2C=CC([N+]([O-])=O)=CN=2)C1)=O>>[CH2:21]([O:22][C:23]([C@@H:25]1[CH2:29][CH2:28][C@H:27]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][N:32]=2)[CH2:26]1)=[O:24])[CH3:1]

Komponenten

4

Edukt 3

HCID 57652073HCID 57652073, VerbindungHCID 66738250HCID 66738250, VerbindungHCID 66738402HCID 66738402, Verbindung

Produkt 1

HCID 57652026HCID 57652026, Verbindung

Versuchsvorschrift

With a method similar to that used for the preparation of (S)-3-(5-amino-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester above, (1R,3S)-3-(5-amino-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester was prepared by the hydrogenation of (1R,3S)-3-(5-nitro-pyridin-2-ylamino)-cyclopentanecarboxylic acid methyl ester. This material was directly used in the next step without further purification.

Aufarbeitung

  1. customThis material was directly used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c6511dc442f547b4a4b1e6b96b589a2d
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08115011B2

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