(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine → (3R)-3-(Pyrrolidin-1-YL)pyrrolidine

HRID 1641899Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1641899
C([N:8]1[CH2:12][CH2:11][C@@H:10]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:13]1([C@@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:17][CH2:16][CH2:15][CH2:14]1

Komponenten

4

Edukt 1

HCID 66629680(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine

Produkt 1

HCID 7176272(3R)-3-(Pyrrolidin-1-YL)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (R)-1′-benzyl-[1,3′]bipyrrolidinyl (0.517 g, 2.24 mmol) in methanol (25 ml) under an atmosphere of argon is treated with palladium hydroxide on carbon (0.1 g). The reaction mixture is placed under an atmosphere of hydrogen, stirred at room temperature overnight and then filtered through Celite™ filter material. The filtrate is concentrated in vacuo to yield the title compound as a dark orange oil.

Aufarbeitung

  1. filtrationfiltered through Celite™
  2. filtrationfilter material
  3. concentrationThe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6a9e0c8e1b69458293c4bc6d6043da63
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08114877B2

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