Methanol → Methyl 2-(piperidin-2-yl)acetate hydrochloride

HRID 1642145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1642145
S(Cl)([Cl:3])=O.Cl.[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[CH2:12][C:13]([OH:15])=[O:14].[CH3:16]O>>[ClH:3].[CH3:16][O:14][C:13](=[O:15])[CH2:12][CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][NH:6]1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 125147122-(Piperidin-2-yl)acetic acid hydrochloride

Produkt 1

HCID 13778732Methyl 2-(piperidin-2-yl)acetate hydrochloride

Versuchsvorschrift

Thionyl chloride (1.8 ml, 25.2 mmol) was added dropwise to a solution, cooled to 0° C., of piperidin-2-ylacetic acid hydrochloride (1.5 g, 8.4 mmol) in methanol (35 ml), and the mixture was heated for 16 h at gentle boiling and then cooled to room temperature. The solvent was removed azeotropically in vacuo with benzene. Yield: 1.3 g (100%)

Aufarbeitung

  1. temperaturethe mixture was heated for 16 h at gentle boiling
  2. customThe solvent was removed azeotropically in vacuo with benzene

Quellen und Nachweise

ORD-Eintrag
ord-7df63a534ee24b9e808de8eae1b73add
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08119633B2

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