5-Bromo-2-chloro-3-methylpyridine → tert-butyl (3aS,6aS)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

HRID 1642164

Reaktionsgleichung

Reaktionsgleichung von HRID 1642164
[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4][C@H:3]2[CH2:6][NH:7][CH2:8][C@@H:2]12.Br[C:17]1[CH:18]=[C:19]([CH3:24])[C:20]([Cl:23])=[N:21][CH:22]=1>>[Cl:23][C:20]1[N:21]=[CH:22][C:17]([N:7]2[CH2:6][C@H:3]3[C@H:2]([N:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]3)[CH2:8]2)=[CH:18][C:19]=1[CH3:24]

Komponenten

3

Edukt 2

HCID 2854345-Bromo-2-chloro-3-methylpyridineHCID 299490891,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate

Produkt 1

HCID 86584376tert-butyl (3aS,6aS)-5-(6-chloro-5-methyl-3-pyridinyl)hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylateAusbeute 41 %

Versuchsvorschrift

The product from Example 15E and 5-bromo-2-chloro-3-methylpyridine were processed as described in Example 1E to provide the title compound (41% yield). MS (DCI/NH3) m/z 338/340 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-0c65e10edfbf4183897f6d67b569c9a4
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08119635B2

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