Methyl 5-bromopyridine-3-carboxylate → Methyl 5-[3-methyl-4-(trifluoromethoxy)phenyl]pyridine-3-carboxylate
Reaktionsgleichung
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[CH3:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][C:18]=1[O:19][C:20]([F:23])([F:22])[F:21]>>[CH3:12][C:13]1[CH:14]=[C:15]([C:2]2[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=[N:4][CH:3]=2)[CH:16]=[CH:17][C:18]=1[O:19][C:20]([F:21])([F:22])[F:23]Komponenten
3
Versuchsvorschrift
2.7 g (12.5 mmol) of methyl 5-bromonicotinate and 3.3 g (15.0 mmol) of [3-methyl-4-(trifluoromethoxy)phenyl]boronic acid were reacted according to the General Method 1A. Yield: 3.1 g (80% of theory)
Quellen und Nachweise
- ORD-Eintrag
- ord-b6eb256e09af422084beea3e367a1d1c
- Quelldatensatz
- uspto-grants-2012_02