3-fluoro-N'-hydroxybenzene-1-carboximidamide → {3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

HRID 1642999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1642999
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=3)[CH2:12][CH:11]([C:25](O)=[O:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:28][C:29]1[CH:30]=[C:31]([C:35](=[N:37]O)[NH2:36])[CH:32]=[CH:33][CH:34]=1>>[F:28][C:29]1[CH:30]=[C:31]([C:35]2[N:37]=[C:25]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:22])[F:24])[CH:16]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:8])[CH2:10]3)[O:26][N:36]=2)[CH:32]=[CH:33][CH:34]=1

Komponenten

3

Edukt 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 580021491-(Morpholin-4-ylcarbonyl)-5-[3-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Produkt 1

HCID 58002328{3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

Versuchsvorschrift

100 mg (0.26 mmol) of the compound from Example 147A and 60 mg (0.39 mmol) of the compound from Example 73A were reacted according to the General Method 2. Yield: 75 mg (57% of theory)

Quellen und Nachweise

ORD-Eintrag
ord-6a93d1b339604641b9b6b6c67658667b
Quelldatensatz
uspto-grants-2012_02
Patentnummer
US08119663B2

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