N-Hydroxypropionimidamide → {3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(3-hydroxypyrrolidin-1-yl)methanone
Reaktionsgleichung
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26]([OH:28])=O)[CH2:10]2)=[O:8])[CH2:3]1.O[N:30]=[C:31]([NH2:34])[CH2:32][CH3:33]>>[CH2:32]([C:31]1[N:34]=[C:26]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:24])([F:25])[F:23])=[CH:19][CH:20]=3)[CH2:14][N:9]([C:7]([N:4]3[CH2:5][CH2:6][CH:2]([OH:1])[CH2:3]3)=[O:8])[CH2:10]2)[O:28][N:30]=1)[CH3:33]Komponenten
3
Versuchsvorschrift
200 mg (0.50 mmol) of the compound from Example 112A and 67 mg (0.75 mmol) of N′-hydroxypropanimidamide were reacted according to the General Method 2. Yield: 17 mg (7% of theory).
Quellen und Nachweise
- ORD-Eintrag
- ord-f909706dcaab4e39ac9cb2db7fbf84ef