D-Pantolactone → (R)-3,3-dimethylbutane-1,2,4-triol

To a stirred suspension of lithium aluminium hydride (3.00 g, 79.1 mmol) in dry THF (100 mL) at 0° C. was added a solution of (R)-pantolactone (10.30 g, 79.14 mmol) in THF (100 mL). The mixture was stirred overnight at room temperature and was then heated to reflux for a further 2 h. The mixture was cooled to 0° C. and the reaction was quenched with saturated aqueous Na2SO4 until a white solid precipitated. The solid was filtered off, the filter cake was washed with THF (2×60 mL) and the filtrate was concentrated under reduced pressure to give the title compound as a pure colorless oil.

1. temperaturewas then heated
2. temperatureto reflux for a further 2 h
3. temperatureThe mixture was cooled to 0° C.
4. customthe reaction was quenched with saturated aqueous Na2SO4 until a white solid
5. customprecipitated
6. filtrationThe solid was filtered off
7. washthe filter cake was washed with THF (2×60 mL)
8. concentrationthe filtrate was concentrated under reduced pressure

ORD-Eintrag

ord-dd6036040f93487aa0036fabe3c69aef

Quelldatensatz

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08119806B2