Reaktionsgleichung
COC(C1C=C(O[C:16]2[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][CH:17]=2)C=C2OC(C)CC=12)=O.[CH3:26][O:27][C:28]([C:30]1[CH:40]=[C:39]([OH:41])[C:33]2[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=2[C:31]=1[F:42])=[O:29]>>[CH3:26][O:27][C:28]([C:30]1[CH:40]=[C:39]([O:41][C:16]2[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][CH:17]=2)[C:33]2[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=2[C:31]=1[F:42])=[O:29]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared in a similar manner as described for Intermediate 1f, from 7-fluoro-4-hydroxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (190a). 1H NMR (400 MHz, CDCl3) δ 7.89-7.94 (m, 2 H) 7.10 (d, J=4.55 Hz, 1 H) 7.04-7.09 (m, 2 H) 3.92 (s, 3 H) 3.07 (s, 3 H) 2.92 (s, 2 H) 1.54 (s, 6 H); LCMS for C22H22FN3O5S m/z 395.00 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-fc107e8c4d254bf69ad50c9a3b2e2e5e
- Quelldatensatz
- uspto-grants-2012_02
- Patentnummer
- US08119624B2
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