Methyl Isobutyl Ketone → Azoxystrobin

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (20 g at 97.1% strength; prepared as described in WO 92/08703) was added to MIBK (77 ml) and water (11 ml), followed by 2-cyanophenyl (8.0 g), DABCO (0.07 g) and potassium carbonate (14.1 g). The reaction was heated to 80° C. and monitored for the end of the reaction (complete after 8 hours). The reaction mixture was washed with water at 80° C. Analysis of the MIBK layer revealed a 95.7% yield of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin).

Herkunft & Nachweise