HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Amino-4,6-dichloropyrimidine → 6-Chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Edukt | 4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline | HCID 16037965 | — |
| Produkt | 6-Chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine | HCID 58733241 | — |
Reaktionsschritte
Analogously to example 8, the title compound is synthesized from 266 mg (1.09 mmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XIX) and 179 mg (1.09 mmol) of 4,6-dichloro-2-pyrimidineamine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07737153B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-3cef52fa6df843c2bd4ac8e11936d6e9 |
| Quellennotiz | uspto-grants-2010_06 |