7-Methoxy-3-methyl-1H-indole-2-carboxylic acid → 3-{4-[(7-methoxy-3-methyl-1H-indole-2-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid ethyl ester
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([C:12]([OH:14])=O)=[C:8]2[CH3:15].[CH2:16]([O:18][C:19]([N:21]1[CH2:25][CH2:24][CH:23]([O:26][C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=2)[CH2:22]1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([N:21]1[CH2:25][CH2:24][CH:23]([O:26][C:27]2[CH:28]=[CH:29][C:30]([NH:33][C:12]([C:9]3[NH:10][C:11]4[C:7]([C:8]=3[CH3:15])=[CH:6][CH:5]=[CH:4][C:3]=4[O:2][CH3:1])=[O:14])=[CH:31][CH:32]=2)[CH2:22]1)=[O:20])[CH3:17]Komponenten
3
Versuchsvorschrift
With a procedure similar to the example above, 3-{4-[(7-methoxy-3-methyl-1H-indole-2-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid ethyl ester was prepared from 7-methoxy-3-methyl-1H-indole-2-carboxylic acid and 3-(4-amino-phenoxy)-pyrrolidine-1-carboxylic acid ethyl ester. LCMS calcd for C24H27N3O5 (m/e) 437, obsd 438 (M+H).