Piperidine → 1-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

HRID 1645868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1645868
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(=O)([O-])O.[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 100841181-Acetyl-4-(4-fluorobenzoylmethyl)piperidine

Produkt 1

HCID 193909281-Acetyl-4-(4-piperidinobenzoylmethyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 516892Sodium BicarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture consisting of 1.84 g of 1-acetyl-4-(4-fluorobenzoylmethyl)piperidine and 5 ml of piperidine was stirred under heating at 100° C. for 20 hours. After completion of the reaction, the reaction mixture was diluted with a saturated aqueous solution of sodium hydrogen carbonate and extracted with ethyl acetate. After drying, the solvent was ditilled off and the oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate) to give 2.2 g of a pale yellow oil.

Aufarbeitung

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. customAfter drying
  4. customthe oily residue was purified by silica gel column chromatography (eluent: ehtyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-0841e85268024aef8b0587b4860f66f6
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05177087

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