Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1645982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1645982
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 19100972Ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate

Produkt 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate, extracted ten times using 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

Aufarbeitung

  1. extractionextracted ten times
  2. dry with materialdried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-ac181c093a2649b2b367672a968e5b01
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05177210

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