HCID 19100941, Verbindung → 5-Chloro-2-methyl-2,7-diazabicyclo[3.3.0]octane
Reaktionsgleichung
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH2:4][CH2:3]2Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
9.3 g (40 mmol) of ethyl 5-chloro-2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate and extracted five times with 50 ml of chloroform each time. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
Aufarbeitung
- concentrationThe mixture is concentrated
- extractionextracted five times with 50 ml of chloroform each time
- dry with materialThe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-36be24fe47a34237925d9de42745eb5a
- Quelldatensatz
- uspto-grants-1993_01
- Patentnummer
- US05177210
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