m-Chloroperbenzoic acid → HCID 15027409, Verbindung

HRID 1646696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1646696
[CH3:1][NH:2][C:3]1[CH:19]=[CH:18][CH:17]=[CH:16][C:4]=1[CH2:5][S:6][C:7]1[NH:11][C:10]2[CH2:12][CH2:13][CH2:14][CH2:15][C:9]=2[N:8]=1.ClC1C=CC=C(C(OO)=[O:28])C=1>C(Cl)(Cl)Cl>[CH3:1][NH:2][C:3]1[CH:19]=[CH:18][CH:17]=[CH:16][C:4]=1[CH2:5][S:6]([C:7]1[NH:8][C:9]2[CH2:15][CH2:14][CH2:13][CH2:12][C:10]=2[N:11]=1)=[O:28]

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 15027408HCID 15027408, Verbindung

Produkt 1

HCID 15027409HCID 15027409, VerbindungAusbeute 25 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 1.20 g (4 mmol) of 2-(2-methylaminobenzylthio)-4,5,6,7-tetrahydro-1H-benzimidazole in chloroform was added under chilling with ice 0.85 g (4 mmol) of 80% m-chloroperbenzoic acid for 20 min. The mixture was then stirred for 15 min. The chloroform portion was washed with a saturated aquesous NaHCO3 solution. The chloroform portion was then extracted with two portions of diluted aqueous NaOH solution. The aqueous extracts were combined, and an excess amount of aqueous NH4Cl was added to the combined extracts to precipitate a crystalline product. The crystalline products were collected by filtration and sufficiently washed. The thus obtained crude crystalline product was recrystallized from dichloromethane/hexane to give 0.32 g of the desired compound as a white crystalline product, yield 25%.

Aufarbeitung

  1. washThe chloroform portion was washed with a saturated aquesous NaHCO3 solution
  2. extractionThe chloroform portion was then extracted with two portions of diluted aqueous NaOH solution
  3. additionan excess amount of aqueous NH4Cl was added to the combined extracts
  4. customto precipitate a crystalline product
  5. filtrationThe crystalline products were collected by filtration
  6. washsufficiently washed
  7. customThe thus obtained crude crystalline product
  8. customwas recrystallized from dichloromethane/hexane

Quellen und Nachweise

ORD-Eintrag
ord-3e051de2b3b04fc282d7e12b40bb5cba
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05180836

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