1,1'-Carbonyldiimidazole → HCID 10465394, Verbindung

HRID 1646751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1646751
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH2:11][CH2:12][NH2:13].[C:14](N1C=CN=C1)(N1C=CN=C1)=[O:15]>O1CCCC1>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:14](=[O:15])[NH:13][CH2:12][CH2:11][C:3]=12

Komponenten

4

Edukt 2

HCID 682631,1'-CarbonyldiimidazoleHCID 118195262-(3-methyl-1H-indol-2-yl)ethan-1-amine

Produkt 1

HCID 10465394HCID 10465394, VerbindungAusbeute 40,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 2-(3-methylindol-2-yl)ethylamine (1.74 g) in tetrahydrofuran (200 ml) at room temperature was added 1,1'-carbonyldiimidazole (1.6 g) in small portions. After one hour of stirring, the reaction mixture was evaporated in vacuo. The residue was dissolved in toluene and the solution was evaporated in vacuo. The oil obtained was heated at 100° C. for 40 minutes and then cooled. Purification of the residue with silica gel column chromatography (chloroform) gave 3,4-dihydro-5-methylpyrimido[1,6-a]indol-1(2H)-one (0.8 g).

Aufarbeitung

  1. customthe reaction mixture was evaporated in vacuo
  2. dissolutionThe residue was dissolved in toluene
  3. customthe solution was evaporated in vacuo
  4. customThe oil obtained
  5. temperaturecooled
  6. customPurification of the residue with silica gel column chromatography (chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-9f6f8476120f4adb95651dbc5db63a48
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05180728

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