Uridine → HCID 14410723, Verbindung

HRID 1647267Notizen

Reaktionsgleichung

[C@@H:1]1(N2C=CC(=O)NC2=O)O[C@H](CO)[C@@H](O)[C@H]1O.[Cl:18][C:19]1[C:20](=[O:35])[NH:21][C:22](=[O:34])[N:23]([CH:33]=1)[C@@H:24]1[O:32][C@H:29]([CH2:30][OH:31])[C@@H:27]([OH:28])[C@H:25]1O>>[CH2:1]=[C:25]1[C@H:27]([OH:28])[C@@H:29]([CH2:30][OH:31])[O:32][C@H:24]1[N:23]1[CH:33]=[C:19]([Cl:18])[C:20](=[O:35])[NH:21][C:22]1=[O:34]

Komponenten

Edukt 2

HCID 6029Uridine

HCID 98385435-Chlorouridine

Produkt 1

HCID 14410723HCID 14410723, Verbindung

Versuchsvorschrift

Protection, oxidation, methylidenation and deprotection reactions were carried out similarly as in Example 7 except that the uridine was replaced by 5-chlorouridine to obtain 2'-methylidene-2'-deoxy-5-chlorouridine.

Quellen und Nachweise

ORD-Eintrag: ord-6ab13943a7724a2aa6e7c73658882595
Quelldatensatz: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05430139

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