HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → [1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Benzimidazol-2-ylmethylamine dihydrochloride hydrate | HCID 145819 | — |
| Edukt | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Edukt | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | [1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester | HCID 67747066 | 88,4% |
Reaktionsschritte
The title compound is prepared by the procedure of Example 1 using 0.505 g of N-(tert-butoxycarbonyl)-L-isoleucine in 10 ml of methylene chloride, 0.500 g of 2-(aminomethyl)benzimidazole dihydrochloride hydrate, 1.07 g of BOP, and 0,850 g of triethylamine. Purification by chromatography (75 g Silica gel; 70% ethyl acetate/hexane) gives 0.669 g of the desired product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05430150 |
| Quelldatensatz | uspto-grants-1995_07 |
| ORD ID | ord-7096213deeb64948bdecfd6cbc428085 |
| Quellennotiz | uspto-grants-1995_07 |