Sodium Hydroxide → HCID 10043588, Verbindung

HRID 1647461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1647461
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][O:18]C(=O)C1C=CC=CC=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[F:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[C:30]([CH3:35])[CH:29]=1.[OH-].[Na+]>O1CCOCC1.CO>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:32][C:31]1[CH:33]=[CH:34][C:28]([F:27])=[CH:29][C:30]=1[CH3:35])=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][OH:18])(=[O:5])[CH:2]([CH3:3])[CH3:4]

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 679824-Fluoro-2-methylanilineHCID 10384366HCID 10384366, Verbindung

Produkt 1

HCID 10043588HCID 10043588, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 3-isobutyryl-4-chloro-8-(benzoyloxymethyl)quinoline (1.84 g, 5 mmol) and 4-fluoro-2-methylaniline (0.78 ml, 7 mmol) in dioxan (25 ml) was heated at reflux for 2 hours, then the solvent evaporated. A solution of sodium hydroxide (0.8 g, 20 mmol) in methanol (50 ml) was added and the mixture stirred at room temperature for 1.5 hours. The resulting precipitate was filtered off and recrystallised from methanol to give (0.48 g, 27%), m.p. 139°-140°.

Aufarbeitung

  1. temperatureat reflux for 2 hours
  2. customthe solvent evaporated
  3. filtrationThe resulting precipitate was filtered off
  4. customrecrystallised from methanol
  5. customto give (0.48 g, 27%), m.p. 139°-140°

Quellen und Nachweise

ORD-Eintrag
ord-283f4b225f1f446cb391f748e3b23f27
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05432182

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