2,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-one → 5-[5-[(3,4-Dihydro-4-oxo-8-propyl-2H-1-benzopyran-7-yl)oxy]pentyloxy]-2-benzofurancarboxylic Acid

HRID 1647991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1647991
[OH:1][C:2]1[CH:12]=[CH:11][C:5]2[C:6](=[O:10])[CH2:7][CH2:8][O:9][C:4]=2[C:3]=1[CH2:13][CH2:14][CH3:15].C([O:18][C:19]([C:21]1[O:22][C:23]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]Br)=[CH:26][C:24]=2[CH:25]=1)=[O:20])C>>[O:10]=[C:6]1[C:5]2[CH:11]=[CH:12][C:2]([O:1][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][O:30][C:27]3[CH:28]=[CH:29][C:23]4[O:22][C:21]([C:19]([OH:20])=[O:18])=[CH:25][C:24]=4[CH:26]=3)=[C:3]([CH2:13][CH2:14][CH3:15])[C:4]=2[O:9][CH2:8][CH2:7]1

Komponenten

3

Edukt 2

HCID 153182992,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-oneHCID 538030785-[(5-Bromopentyl)oxy]-2-benzofurancarboxylic Acid Ethyl Ester

Produkt 1

HCID 152950025-[5-[(3,4-Dihydro-4-oxo-8-propyl-2H-1-benzopyran-7-yl)oxy]pentyloxy]-2-benzofurancarboxylic Acid

Versuchsvorschrift

Starting with 0.207 g (1.00 mmol) of 2,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-one, and 0.355 g (1.00 mmol) of 5-[(5-bromopentyl)oxy]-2-benzofurancarboxylic acid ethyl ester, there was obtained 0.093 g (20.5%) of the title compound as an off-white solid, mp 192°-195° C. (recrystallized from hexane-ethyl acetate), using the procedure of example 22.

Aufarbeitung

  1. customthere was obtained
  2. custom0.093 g (20.5%) of the title compound as an off-white solid, mp 192°-195° C. (recrystallized from hexane-ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-2674c9f5a4c1443f8955a40a6137eb0f
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05434186

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