2,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-one → 6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648190
[C:1]1([C:7]2[C:8](=[O:16])O[C:10](C)(C)[O:11][C:12]=2[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=[N:18][C:19]([CH3:28])([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=1)[CH3:20]>>[CH3:13][C:12]1[O:11][CH2:10][N:18]([C:19]([CH3:28])([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=2)[CH3:20])[C:8](=[O:16])[C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 131570242,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-oneHCID 15300847N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine2×

Produkt 1

HCID 199189486-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-oneAusbeute 69,9 %

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (1.0 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (Compound of Example 3) (0.76 g) was heated at 15 0° C. for 30 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (1.0 g).

Aufarbeitung

  1. customThe reaction mixture was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-7282cd606f3b45d1a4b6c39e385160a4
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436224

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