N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine → 5-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648194
[CH2:1]([C:5]1[C:6](=[O:14])O[C:8](C)(C)[O:9][C:10]=1[CH3:11])[CH:2]([CH3:4])[CH3:3].C=[N:16][C:17]([CH3:26])([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[CH3:18]>C1(C)C(C)=CC=CC=1>[CH2:1]([C:5]1[C:6](=[O:14])[N:16]([C:17]([CH3:26])([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:18])[CH2:8][O:9][C:10]=1[CH3:11])[CH:2]([CH3:3])[CH3:4]

Komponenten

4

Edukt 2

HCID 15300847N-methylene-1-methyl-1-(3-chlorophenyl)ethylamineHCID 199189545-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one

Produkt 1

HCID 199189625-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-oneAusbeute 54,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

Xylene (1 ml) was added to a mixture of 5-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.59 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (0.55 g), and the resulting mixture was heated at reflux for 60 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.52 g).

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 60 minutes for reaction
  3. customThe reaction mixture was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-116adac64a8a438e812a14abc08bb7f8
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436224

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