Acetonitrile → 2-Methylquinazoline

HRID 1648248

Reaktionsgleichung

Reaktionsgleichung von HRID 1648248
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Komponenten

3

Edukt 2

HCID 6342AcetonitrileHCID 760802-Aminobenzophenone

Produkt 1

HCID 5889872-Methylquinazoline

Versuchsvorschrift

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Quellen und Nachweise

ORD-Eintrag
ord-24ef11ca3139447cbf6d3fe0c9ffbb64
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436247

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