Acetonitrile → 2-Methylquinazoline
Reaktionsgleichung
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1Komponenten
3
Versuchsvorschrift
In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.
Quellen und Nachweise
- ORD-Eintrag
- ord-24ef11ca3139447cbf6d3fe0c9ffbb64
- Quelldatensatz
- uspto-grants-1995_07
- Patentnummer
- US05436247
Notizen zur Reaktion
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