1-(1H-indol-3-yl)-2-methylpropan-2-amine → [2-(1H-indol-3-yl)-1,1-dimethylethyl][2-(2-ethyloxy-phenoxy)ethyl]amine hydrochloride

HRID 1648395

Reaktionsgleichung

Reaktionsgleichung von HRID 1648395
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][CH3:17])(=O)=O.[Cl:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][CH:23]=[C:22]2[CH2:28][C:29]([NH2:32])([CH3:31])[CH3:30].N1C2C(=CC=CC=2)C(CC(N)(C)C)=C1>>[ClH:18].[NH:24]1[C:25]2[C:21](=[CH:20][CH:19]=[CH:27][CH:26]=2)[C:22]([CH2:28][C:29]([NH:32][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH3:17])([CH3:30])[CH3:31])=[CH:23]1

Komponenten

4

Edukt 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 152899942-(2-Ethoxyphenoxy)ethyl methanesulfonate

Produkt 1

HCID 19919947[2-(1H-indol-3-yl)-1,1-dimethylethyl][2-(2-ethyloxy-phenoxy)ethyl]amine hydrochloride

Versuchsvorschrift

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-(2-ethyloxyphenoxy)ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl][2-(2-ethyloxy-phenoxy)ethyl]amine hydrochloride, m.p. 184°-186° C.

Quellen und Nachweise

ORD-Eintrag
ord-10990cfc08cb465c8b9137d67f93de25
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436264

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