5-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamine → [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(but-1-yloxy)phenoxy]ethyl}amine hydrochloride

HRID 1648398

Reaktionsgleichung

Reaktionsgleichung von HRID 1648398
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH2:16][CH2:17][CH2:18][CH3:19])(=O)=O.[Cl:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[C:24]2[CH2:30][C:31]([NH2:34])([CH3:33])[CH3:32].N1C2C(=CC=CC=2)C(C(C)(C)CN)=C1>>[ClH:20].[NH:26]1[C:27]2[C:23](=[CH:22][CH:21]=[CH:29][CH:28]=2)[C:24]([CH2:30][C:31]([NH:34][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH2:18][CH3:19])([CH3:32])[CH3:33])=[CH:25]1

Komponenten

4

Edukt 3

HCID 132605-Chloro-alpha,alpha-dimethyl-1H-indole-3-ethanamineHCID 27303beta,beta-Dimethyl-1H-indole-3-ethanamineHCID 152899962-[2-(But-1-yloxy)phenoxy]ethyl methanesulfonate

Produkt 1

HCID 19919960[2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(but-1-yloxy)phenoxy]ethyl}amine hydrochloride

Versuchsvorschrift

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-[2-(but-1-yloxy)phenoxy]ethyl methanesulfonate and [2-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-2-methylprop-1-yl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl]{2-[2-(but-1-yloxy)phenoxy]ethyl}amine hydrochloride, m.p. 150°-152° C.

Quellen und Nachweise

ORD-Eintrag
ord-8309191587644a1cbc1b2f39689a0bab
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436264

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