2,3-Bis(mercaptoisobutryl) propionic acid → 2,3-Bis(mercaptoisobutryl)propanol

HRID 1648504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648504
[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[C:6](O)=[O:7])=[O:4]>O1CCCC1.B.C1COCC1>[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[CH2:6][OH:7])=[O:4]

Komponenten

4

Edukt 1

HCID 867445382,3-Bis(mercaptoisobutryl) propionic acid

Produkt 1

HCID 867445372,3-Bis(mercaptoisobutryl)propanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 2723981Borane;tetrahydrofuranLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 2,3-bis(mercaptoisobutryl) propionic acid 9 (Scheme 1) (1 mmol) in 10 mL of anhydrous tetrahydrofuran, 1.5 mL of 1M BH3.THF is added over a period of 5 minutes (min.). The solution is stirred for another 10 min. and evaporated to dryness. Ten ml of water is added to the residue and the mixture is extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated in vacuo to give the product 21, which is purified by flash column chromatography.

Aufarbeitung

  1. customevaporated to dryness
  2. additionTen ml of water is added to the residue
  3. extractionthe mixture is extracted with ethyl acetate
  4. washThe organic layer is washed with water
  5. customdried
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fb40702f5097419ba1326776339c536e
Quelldatensatz
uspto-grants-1995_07
Patentnummer
US05436352

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