3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 4-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

HRID 1648747Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648747
[C:1]([C:5]1[CH:10]=[C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][C:6]=1[OH:17])([CH3:4])([CH3:3])[CH3:2].Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>N1C=CC=CC=1>[C:19]([O:17][C:6]1[CH:7]=[CH:8][C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:10][C:5]=1[C:1]([CH3:4])([CH3:2])[CH3:3])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

Komponenten

4

Edukt 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 97946452-t-butyl-4-cyclohexylphenol

Produkt 1

HCID 1985864-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

12 g (52 mmol) of 2-t-butyl-4-cyclohexylphenol and 10 g (56 mmol) of nicotinic acid chloride hydrochloride was mixed with 150 ml of dry pyridine and stirred for 48 hours at 35° C. After cooling precipitated pyridine hydrochloride was sucked off and the filtrate mixed with 75 ml of water. The precipitated raw product was freed from pyridine by washing with water and recrystallized from alcohol.

Aufarbeitung

  1. temperatureAfter cooling
  2. customprecipitated pyridine hydrochloride
  3. additionthe filtrate mixed with 75 ml of water
  4. customThe precipitated raw product
  5. washby washing with water
  6. customrecrystallized from alcohol

Quellen und Nachweise

ORD-Eintrag
ord-b97418d47680424a80a3cfb888d6e53d
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04412998

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