Methyl Isocyanate → HCID 13228806, Verbindung

HRID 1648764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648764
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH3:7][N:8]=[C:9]=[O:10]>C(N(CC)CC)C.C(Cl)Cl>[CH3:7][NH:8][C:9]([N:5]([O:6][C:9]([NH:8][CH3:7])=[O:10])[C:1](=[O:4])[CH2:2][CH3:3])=[O:10]

Komponenten

5

Edukt 2

HCID 12228Methyl IsocyanateHCID 75743N-Hydroxypropanamide

Produkt 1

HCID 13228806HCID 13228806, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Propiohydroxamic acid (4.5 grams), methyl isocyanate (6.0 grams), and a few drops of triethylamine were stirred for about one hour in about 50 ml of methylene chloride. The resulting solution was allowed to stand at room temperature for about 48 hours, after which the solvent was removed by evaporation leaving a residue. The residue was recrystallized from a mixture of methylene chloride and hexane leaving the desired, N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)-oxy)propionamide as white crystals, m.p. 90.5°-92.5° C.

Aufarbeitung

  1. customafter which the solvent was removed by evaporation
  2. customleaving a residue
  3. customThe residue was recrystallized from a mixture of methylene chloride and hexane leaving the

Quellen und Nachweise

ORD-Eintrag
ord-1849293a7a1545c9abd3053cf99f1cbd
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04413009

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