Ethyl isocyanate → N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

HRID 1648765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1648765
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH2:7]([N:9]=[C:10]=[O:11])[CH3:8]>C(N(CC)CC)C.C(Cl)Cl>[CH2:7]([NH:9][C:10]([N:5]([O:6][C:10]([NH:9][CH2:7][CH3:8])=[O:11])[C:1](=[O:4])[CH2:2][CH3:3])=[O:11])[CH3:8]

Komponenten

5

Edukt 2

HCID 8022Ethyl isocyanateHCID 75743N-Hydroxypropanamide

Produkt 1

HCID 13228807N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Propiohydroxamic acid (4.5 grams), ethyl isocyanate (8.0 grams), and a few drops of triethylamine were added to 100 ml of methylene chloride and allowed to stand at room temperature for about 12 hours. The solvent was then removed under vacuum leaving a residue which was recrystallized from a solution of methylene chloride and hexane leaving the desired, N-((ethylamino)carbonyl)-N-(((ethylamino)carbonyl)oxy)propionamide as white crystals, m.p. 104°-106° C.

Aufarbeitung

  1. customThe solvent was then removed under vacuum
  2. customleaving a residue which
  3. customwas recrystallized from a solution of methylene chloride and hexane leaving the

Quellen und Nachweise

ORD-Eintrag
ord-927f6c10ae484f9babd8e38cfc30aa76
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04413009

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