HCID 13317110, Verbindung → HCID 13317111, Verbindung

HRID 1649204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1649204
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2)(=[O:3])[CH3:2]>O1CCOCC1.[C].[Pd]>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11][CH2:10]2)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 13317110HCID 13317110, Verbindung

Produkt 1

HCID 13317111HCID 13317111, VerbindungAusbeute 0,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

8-Acetylaminocarbostyril (15.0 g, 74.2 mols) was suspended in 300 ml of dioxane. After adding 2.0 g of 10% palladium-carbon, the suspension was subjected to catalytic reduction at 70° to 80° C. under atmospheric pressure. After completion of reaction, the catalyst was removed by filtration and the solvent was distilled off under reduced pressure to give 14.3 g of 8-acetylamino-3,4-dihydrocarbostyril.

Aufarbeitung

  1. customwas subjected to catalytic reduction at 70° to 80° C. under atmospheric pressure
  2. customAfter completion of reaction
  3. customthe catalyst was removed by filtration
  4. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-754a5691ddc048f6885fda1de4e785a1
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04415572

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