Sodium Hydroxide → 8-Aminoquinolin-2(1H)-one

HRID 1649206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1649206
C([NH:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]=[CH:10]2

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 13317110HCID 13317110, Verbindung

Produkt 1

HCID 133171128-Aminoquinolin-2(1H)-oneAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

8-Acetylaminocarbostyril (21.5 g, 0.106 mol) was suspended in 190 ml of 20% hydrochloric acid and the suspension was stirred while heating under reflux for 1 hour. The reaction mixture was poured into ice water and neutralized with 5 N sodium hydroxide. Crystals which formed were collected by filtration to give 15.47 g of 8-aminocarbostyril.

Aufarbeitung

  1. temperaturewhile heating
  2. temperatureunder reflux for 1 hour
  3. customCrystals which formed
  4. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-6d38258e6bc741be942b36a5bb376208
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04415572

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