Bromoform → 2-Bromo-5,6-dichloro-3-nitropyrazine
Reaktionsgleichung
C(ON=O)CC(C)C.[Cl:9][C:10]1[N:11]=[C:12]([N+:18]([O-:20])=[O:19])[C:13](N)=[N:14][C:15]=1[Cl:16].C(Br)(Br)[Br:22]>>[Br:22][C:13]1[C:12]([N+:18]([O-:20])=[O:19])=[N:11][C:10]([Cl:9])=[C:15]([Cl:16])[N:14]=1Komponenten
4
Versuchsvorschrift
To 4.8 g isoamylnitrite in 150 ml bromoform heated to 95°-100° is added portionwise 5.0 g 5,6-dichloro-3-nitro-pyrazinamine. The reaction mixture is heated at reflux for 18 hours. After cooling, the bromoform is removed in vacuo to give an oil which is chromatographed on silica gel. The initial component to elute is 5,6-dichloro-2-bromonitropyrazine, which is obtained (2.6 g) as a viscous oil.
Aufarbeitung
- temperatureThe reaction mixture is heated
- temperatureat reflux for 18 hours
- temperatureAfter cooling
- customthe bromoform is removed in vacuo
- customto give an oil which
- customis chromatographed on silica gel
- washThe initial component to elute
- customwhich is obtained (2.6 g) as a viscous oil
Quellen und Nachweise
- ORD-Eintrag
- ord-d6c1fbabf9d14d2680ff4e9bb4e34afb
- Quelldatensatz
- uspto-grants-1983_11
- Patentnummer
- US04416882
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